The Cytonix Corporation, which was founded in 1985 as CytoFluidics, Inc., began as a startup company in the University of Maryland Technology Advancement Program.  Initial goals were the development of proprietary concepts for digital microfluidic circuits using electrowetting of hydrophobic surfaces and for 2-fluid control systems with hydrophobic and hydrophilic micro structures. Substantial effort was focused on the development of hydrophilic, hydrophobic and super-hydrophobic coatings and resists. These efforts, aided by a 1989 Phase II grant from NSF, resulted in a broad range of intellectual property.  Digital PCR methods and technology, co-invented in 1995 in a collaboration with the National Institutes of Health, were purchased by Life Technologies in June 2009, and reorganization of the Cytonix Corporation led to the formation of Cytonix LLC. Located in Beltsville, Maryland, Cytonix LLC manufactures hydrophobic and oleophobic coating and additive products for life sciences, electronics, aerospace and communications. Products are sold directly and through other manufacturers and distributors world wide. Current research initiatives involve Digital PCR and electrowetting-based microfluidics, with continued development of fluorinated coatings and additives.